Title : Metasurfaces for biosensing, molecular diagnostics, and biomedical imaging
일시 : 2024년 10월 8일(화), 17시
Speaker : 김인기 Prof. Inki Kim (Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University)
Abstract :
In this talk, I will introduce metasurface-enhanced multiplexed nanospectroscopy, molecular diagnostics and biomedical imaging technologies. In detail, I will explain plasmonic resonance energy transfer for real-time cell monitoring, fluorescence correlation spectroscopy for single molecule detection, ultrafast metaphotonic PCR, and multimodal photoacoustic microscopes.
Nowadays, the emergence of technologies for precision health and early disease diagnosis benefits from inexpensive and sensitive devices that can provide abundant information about molecule composition and their structural arrangements, cell secretome and morphology, and the presence of viruses in biological samples. Optical metasurfaces have proven to be a promising solution for advanced biosensing assay and bioimaging settings thanks to their engineerable properties of light manipulation via designing unit cell structures. On the other hand, new fields of quantum life sciences and spatial omics driven by precise manipulation of incident light properties show clear benefits of empowered diagnostics and remote therapeutics. However, the metasurface functionalities in those fields remain largely unexplored [1].
In this talk, I will introduce metasurface-enhanced multiplexed nanospectroscopy, molecular diagnostics and biomedical imaging technologies. First, we report metasurfaces-driven hyperspectral imaging via multiplexed plasmon resonance energy transfer (PRET) to probe biological light-matter interactions, which can detect quantum biological electron transfer (QBET) [2]. Second, we introduce a dielectric metalens device of submicrometer thickness for integrating single molecule on-chip sensors for point-of-care testing and quantum coherence energy transfer. The high numerical aperture, high focusing efficiency, and dual-wavelength operation of the metalens enables the implementation of fluorescence correlation spectroscopy with a single Alexa 647 molecule in the focal volume [3]. Third, we demonstrate a fast metaphotonic PCR device composed of a metamaterial perfect absorber that can rapidly go through thermocycling steps using a single infrared LED for quantitative studies of quantum enzymology [4]. Last, we introduce multimodal biomedical imaging technologies like phase contrast imaging or edge detection for cell and tissue morphology analysis and multifunctional photoacoustic microscope for label free volumetric imaging [5].
References
[1] Barulin, A. and Kim, I+ et al. (2024), ACS Photonics 11, 904-916.
[2] Kim, I et al. (2023), Advanced Materials 35, 2300229,
[3] Barulin, A. and Kim, I+ et al. (2024), Nature Communications 15, 26
[4] Kim, I+ et al. (2024), Advanced Materials, 2311931 (https://doi.org/10.1002/adma.202311931)
[5] Barulin, A. and Kim, I et al. Science Advances (in revision)